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PRMT5-IN-1 hydrochloride

Product Specifications

Target

Histone Methyltransferase, Others

Related Pathways

Others, Chromatin/Epigenetic

Bioactivity

PRMT5 IN-1 hydrochloride (compound 9) is a hemiacetalamine and a potent inhibitor of selective protein arginine methyltransferase 5 (PRMT5), exhibiting an inhibitory effect on PRMT5/MEP50 with an IC50 of 11 nM. Under physiological conditions, it can be converted to an aldehyde and reacts with C449 to form a covalent adduct.

Molecular Formula

C19H20Cl2N4O5

Molecular Weight

455.29

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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