BS-181 dihydrochloride
Product Specifications
CAS Number
1883548-83-1
Target
Others, CDK
Related Pathways
Cell Cycle/Checkpoint, Others
Bioactivity
BS-181 dihydrochloride is a selective and potent inhibitor of CDK7 with an IC50 value of 21 nM. BS-181 dihydrochloride inhibits CDK2 (IC50: 880 nM), CDK5 (IC50: 3000 nM) and CDK9 (IC50: 4200 nM), but does not block CDK1, 4 and 6. BS-181 dihydrochloride inhibits the growth of a group of cancer cells (IC50: 11.5 μM-37.3 μM) and induces apoptosis.
Smiles
Cl.Cl.CC(C)c1cnn2c(NCc3ccccc3)cc(NCCCCCCN)nc12
Molecular Formula
C22H34Cl2N6
Molecular Weight
453.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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