TPB15
Product Specifications
CAS Number
2170347-69-8
Target
Apoptosis, Others, Hedgehog/Smoothened, Smo
Related Pathways
GPCR/G Protein, Apoptosis, Stem Cells, Others
Bioactivity
TPB15 is an orally active inhibitor of Hh (Hedgehog) signalling. TPB15 significantly blocks the MDA-MB-468 cell cycle and induces apoptosis. TPB15 blocks Smo (Smoothened) translocation into cilia and reduces Smo protein and mRNA expression. TPB15 has good anti-tumour effects and low toxicity.
Smiles
ClC=1C(C=2N3C(=NN2)C(Cl)=CC=C3)=CC(NC(=O)C4=C(Cl)N=C(Cl)C=C4)=CC1
Molecular Formula
C18H9Cl4N5O
Molecular Weight
453.11
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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