KRAS inhibitor-16
Product Specifications
CAS Number
2230873-67-1
Target
Others, Kras, Ras
Related Pathways
GPCR/G Protein, Others, MAPK
Bioactivity
KRAS inhibitor-16 (compound 3-11) is a potent inhibitor of KRAS G12C (IC50: 0.457 μM) and exhibits p-ERK inhibition in MIA PaCA-2 and A549 cells with IC50s of 3.06 and 11.1 μM, respectively. KRAS inhibitor-16 has potential for study in pancreatic, colorectal, and lung cancers.
Smiles
FC=1C=2C(=C(SN2)N3CCN(C(C=C)=O)CC3)C=C(Cl)C1C4=C(Cl)C=CC(O)=C4
Molecular Formula
C20H16Cl2FN3O2S
Molecular Weight
452.33
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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