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KRAS inhibitor-12

Product Specifications

CAS Number

2230874-00-5

Target

Ras|||Kras|||Others

Related Pathways

GPCR/G Protein|||MAPK|||Others

Bioactivity

KRAS inhibitor-12 (compound 6-1) is a potent inhibitor of KRAS G12C (IC50: 0.537 ?M), exhibiting p-ERK inhibition in MIA PaCA-2 and A549 cells with IC50 values of 1.3 and 3.7 ?M, respectively. KRAS inhibitor-12 has potential for study in pancreatic, colorectal, and lung cancers.

Smiles

FC=1C=2C(=C(SN2)N3CCN(C(C=C)=O)CC3)C=C(Cl)C1C4=C(Cl)C=CC(N)=N4

Molecular Formula

C19H16Cl2FN5OS

Molecular Weight

452.33

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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