KRAS inhibitor-15
Product Specifications
CAS Number
2230873-75-1
Target
Ras, Others, Kras
Related Pathways
MAPK, GPCR/G Protein, Others
Bioactivity
KRAS inhibitor-15 (compound 3-19) is a potent inhibitor of KRAS G12C with an IC50 of 0.954 μM. It exhibits p-ERK inhibition in MIA PaCA-2 and A549 cells with IC50s of 2.03 μM and >33.3 μM, respectively. KRAS inhibitor-15 has potential for study in pancreatic, colorectal, and lung cancers.
Smiles
FC=1C=2C(=C(SN2)N3CCN(C(C=C)=O)CC3)C=C(Cl)C1C4=C(Cl)C=CC(N)=C4
Molecular Formula
C20H17Cl2FN4OS
Molecular Weight
451.34
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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