MIDH1-IN-1
Product Specifications
CAS Number
2757155-96-5
Target
Others, Isocitrate Dehydrogenase (IDH)
Related Pathways
Others, Metabolism
Bioactivity
MIDH1-IN-1 (compound 43) is a potent and selective inhibitor of mIDH1 (isocitrate dehydrogenase 1 mutant) with an IC50 of 961.5 nM, and it effectively inhibits the production of 2-HG (2-hydroxyglutarate) in HT1080 cells. It also exhibits significant anti-proliferative effects on IDH1 mutant U-87 cells (IC50: 41.8 nM) . mIDH1-IN-1 is an anti-tumor agent used to study IDH1 mutant solid tumors.
Smiles
C(N(C(C#C)=O)C1=CC=C(N(=O)=O)C=C1)(C(NC2CCCCC2)=O)C3=C(C)C=C(OC)C=C3
Molecular Formula
C25H27N3O5
Molecular Weight
449.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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