PDE5-IN-3
Product Specifications
CAS Number
2538149-57-2
Target
Others, PDE, Apoptosis, EGFR, Wnt/beta-catenin
Related Pathways
JAK/STAT signaling, Tyrosine Kinase/Adaptors, Metabolism, Others, Apoptosis, Stem Cells, Angiogenesis, Cytoskeletal Signaling
Bioactivity
PDE5-IN-3 (compound 11j) is a potent inhibitor of PDE5 (IC50: 1.57 nM) and has a moderate inhibitory effect on EGFR (IC50: 5.827 μM) . It markedly inhibits the Wnt/β-catenin pathway (IC50: 1286.96 ng/mL), induces the intrinsic apoptotic mitochondrial pathway in HepG2 cells, and exhibits significant antitumor effects.
Smiles
O=C1C2=C(N(N=C2)C3=CC=C(Br)C=C3)NC(=N1)C=4C(OC)=NC5=C(C4)C=CC=C5
Molecular Formula
C21H14BrN5O2
Molecular Weight
448.27
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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