Glucosylceramide synthase-IN-2
Product Specifications
CAS Number
2597958-02-4
Target
Others, Transferase
Related Pathways
Metabolism, Others
Bioactivity
Glucosylceramide synthase-IN-2 (compound T-690) is a potent, blood-brain barrier-permeable, orally active inhibitor of glucosylceramide synthase (GCS), with IC50 values of 15 nM for human GCS and 190 nM for mouse GCS. It exhibits non-competitive inhibition of C8 ceramide and UDP glucose.
Smiles
CC(C)(O)c1ccc(NC(=O)c2ccnn(-c3ccccc3OCC(F)(F)F)c2=O)cc1
Molecular Formula
C22H20F3N3O4
Molecular Weight
447.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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