FGFR3-IN-5
FGFR3-IN-5 is a potent and selective FGFR3 inhibitor with IC50 values of 3, 44, and 289 nM for FGFR3, FGFR2, and FGFR1, respectively. FGFR3-IN-5 can be used in research of cancer[1].
Product Specifications
CAS Number
[2446664-72-6]
UNSPSC
12352005
Target
FGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fgfr3-in-5.html
Concentration
10mM
Purity
99.16
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 160°C)
Smiles
N#CC1=C2C(OC)=CC(C3=CN(C4CCN(CC4)C(C5(CN(C5)C(C=C)=O)F)=O)N=C3)=CN2N=C1
Molecular Formula
C24H24FN7O3
Molecular Weight
477.49
References & Citations
[1]James FB, et, al. Substituted pyrazolo[1,5-a]pyridine compounds as inhibitors of fgfr tyrosine kinases. WO2020131627.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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