WEHI-150
Product Specifications
CAS Number
70492-21-6
Target
DNA Alkylator/Crosslinker, Others
Related Pathways
DNA Damage/DNA Repair, Others
Bioactivity
WEHI-150 is an analog of mitoxantrone, a DNA interstrand cross-linker (t1/2=12.5 h) . WEHI-150 is capable of forming covalent adducts on CpG sequences, with a particular preference for methylated CpG sites. Formaldehyde-activated WEHI-150 induces DNA interstrand cross-linking and blocks transcription in a concentration-dependent manner. WEHI-150 mediates the formation of covalent adducts that do not interact with guanine N-2 and forms adducts on new DNA sequences.
Smiles
N(CCNCCN)C1=C2C(=C(NCCNCCN)C=C1)C(=O)C=3C(C2=O)=C(O)C=CC3O
Molecular Formula
C22H30N6O4
Molecular Weight
442.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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