AMG-8718
Product Specifications
CAS Number
1215868-94-2
Target
Beta-Secretase, Others
Related Pathways
Others, Neuroscience
Bioactivity
AMG-8718 is a selective, orally active and potent BACE1 inhibitor that acts on both BACE1 (IC50: 0.0007 μM) and BACE2 (IC50: 0.005 μM) . AMG-8718 significantly reduces CSF and Aβ40 levels in the brain.
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NC1=N[C@]2(C=3C(OC=4C2=CC(C#CC5(C)COC5)=CN4)=CC=C(C3)C6=C(F)N=CC=C6)CO1
Molecular Formula
C25H19FN4O3
Molecular Weight
442.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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