JAK-IN-23
Product Specifications
Target
Others, STING, NF-κB, STAT, JAK
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, Immunology/Inflammation, JAK/STAT signaling, NF-κB, Others, Chromatin/Epigenetic, Stem Cells
Bioactivity
JAK-IN-23 is an orally active dual JAK/STAT and NF-κB inhibitor that inhibits JAK1 (IC50: 8.9 nM), JAK2 (IC50: 15 nM), and JAK3 (IC50: 46.2 nM) . It exhibits strong anti-inflammatory effects and can reduce the release of various pro-inflammatory factors. JAK-IN-23 can be used to study inflammatory bowel disease (IBD) .
Molecular Formula
C23H22Cl2N4O
Molecular Weight
441.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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