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TRK-IN-12

Product Specifications

CAS Number

2823342-34-1

Target

Others, Trk receptor

Related Pathways

Others, Tyrosine Kinase/Adaptors

Bioactivity

TRK-IN-12 (Compound 9e), a macrocyclic derivative, is a potent TRK inhibitor, with efficacy against TRK G595R (IC 50 = 13.1 nM) . It demonstrates significant antiproliferative activity in the Ba/F3-LMNA-NTRK1 cell line (IC 50 = 0.080 μM) and exhibits superior inhibitory performance (IC 50 = 0.646 μM) compared to the control agent LOXO-101 in the Ba/F3-LMNA-NTRK1-G595R cell line [1].

Smiles

S(CCl)(=O)(=O)N1CC2=C3N(N=C2)C=CC(=N3)N(C)CC=4C(OCC1)=CC=C(F)C4

Molecular Formula

C18H19ClFN5O3S

Molecular Weight

439.89

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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