TRK-IN-12
Product Specifications
CAS Number
2823342-34-1
Target
Others, Trk receptor
Related Pathways
Others, Tyrosine Kinase/Adaptors
Bioactivity
TRK-IN-12 (Compound 9e), a macrocyclic derivative, is a potent TRK inhibitor, with efficacy against TRK G595R (IC 50 = 13.1 nM) . It demonstrates significant antiproliferative activity in the Ba/F3-LMNA-NTRK1 cell line (IC 50 = 0.080 μM) and exhibits superior inhibitory performance (IC 50 = 0.646 μM) compared to the control agent LOXO-101 in the Ba/F3-LMNA-NTRK1-G595R cell line [1].
Smiles
S(CCl)(=O)(=O)N1CC2=C3N(N=C2)C=CC(=N3)N(C)CC=4C(OCC1)=CC=C(F)C4
Molecular Formula
C18H19ClFN5O3S
Molecular Weight
439.89
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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