Ipatasertib
Product Specifications
CAS Number
1001264-89-6
Target
Apoptosis, Akt
Related Pathways
PI3K/Akt/mTOR signaling, Cytoskeletal Signaling, Apoptosis
Purity
0.9979
Bioactivity
Ipatasertib (GDC-0068) is a selective, ATP-competitive pan-Akt inhibitor that inhibits Akt1 (IC50:5 nM), Akt2 (IC50:18 nM), and Akt3 (IC50:8 nM) . Ipatasertib (GDC-0068) can lead to p53-independent PUMA activation by inhibiting Akt, thereby activating FoxO3a and NF-κB simultaneously, directly binding to the PUMA promoter, upregulating PUMA transcription and Bax-mediated intrinsic mitochondrial apoptosis.
Smiles
C[C@H]1C2=C(N=CN=C2[C@H](O)C1)N3CCN(C([C@H](CNC(C)C)C4=CC=C(Cl)C=C4)=O)CC3
Molecular Formula
C24H32ClN5O2
Molecular Weight
458
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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