HDAC-IN-46
Product Specifications
CAS Number
2562386-85-8
Target
Apoptosis|||Others|||HDAC
Related Pathways
Chromatin/Epigenetic|||Apoptosis|||Others|||DNA Damage/DNA Repair
Bioactivity
HDAC-IN-46 (compound 12c) is a potent inhibitor of HDAC, targeting HDAC1 (IC50: 0.21 ?M) and HDAC6 (IC50: 0.021 ?M) . It upregulates p-p38, downregulates Bcl-xL and cyclin D1 in MDA-MB-231 cells, blocks the cell cycle in the G2 phase, and induces apoptosis, making it useful for triple negative breast cancer (TNBC) studies.
Smiles
C(C)C=1C(C2=CC=C(C=C2)C3=CN(CCCCCCCC(NO)=O)N=N3)=C(N)N=C(N)N1
Molecular Formula
C22H30N8O2
Molecular Weight
438.53
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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