Avagacestat
Product Specifications
CAS Number
1146699-66-2
Target
Gamma-secretase
Related Pathways
Neuroscience, Proteases/Proteasome, Stem Cells
Purity
0.9977
Bioactivity
Avagacestat (BMS-708163) (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2.
Smiles
NC(=O)[C@@H](CCC(F)(F)F)N(Cc1ccc(cc1F)-c1ncon1)S(=O)(=O)c1ccc(Cl)cc1
Molecular Formula
C20H17ClF4N4O4S
Molecular Weight
520.89
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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