Avagacestat

Product Specifications

CAS Number

1146699-66-2

Target

Gamma-secretase

Related Pathways

Neuroscience, Proteases/Proteasome, Stem Cells

Purity

0.9977

Bioactivity

Avagacestat (BMS-708163) (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2.

Smiles

NC(=O)[C@@H](CCC(F)(F)F)N(Cc1ccc(cc1F)-c1ncon1)S(=O)(=O)c1ccc(Cl)cc1

Molecular Formula

C20H17ClF4N4O4S

Molecular Weight

520.89

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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