XL888
Product Specifications
CAS Number
1149705-71-4
Target
HSP, Apoptosis
Related Pathways
Metabolism, Apoptosis, Cytoskeletal Signaling
Purity
0.9918
Bioactivity
XL888 is an ATP-competitive inhibitor of Hsp90 (IC50: 24 nM) . Heat shock protein 90 (Hsp90) is a chaperone that maintains the functionality of client proteins involved in cell proliferation, cell cycling, and apoptosis. Through this action, specific client proteins are degraded, resulting in cell cycle arrest or apoptosis. XL888 is orally bioavailable and shows efficacy in tumor regression in gastric carcinoma and melanoma xenografts in mice.
Smiles
CC[C@@H](C)Nc1cc(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3c2ccc(cn2)C(=O)C2CC2)c(C)cc1C(N)=O
Molecular Formula
C29H37N5O3
Molecular Weight
503.64
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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