TYK2-IN-12
Product Specifications
CAS Number
2244061-66-1
Target
JAK, Others, IFNAR
Related Pathways
Others, Tyrosine Kinase/Adaptors, Immunology/Inflammation, JAK/STAT signaling, Chromatin/Epigenetic, Stem Cells, Angiogenesis
Bioactivity
TYK2-IN-12 (compound 30) is a selective, orally active inhibitor of TYK2 (tyrosine kinase 2) (Ki: 0.51 nM) . It inhibits IL-12-induced IFNγ in human and mouse whole blood with IC50 values of 2.7 and 7.0 μM, respectively, and can be used to study psoriasis.
Smiles
N(C1=C2C(=NC(=C1)C3=C(F)C=CC=C3F)CNC2=O)C4=CC=C(C(=O)N5CCCC5)C=C4
Molecular Formula
C24H20F2N4O2
Molecular Weight
434.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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