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TYK2-IN-12

Product Specifications

CAS Number

2244061-66-1

Target

JAK, Others, IFNAR

Related Pathways

Others, Tyrosine Kinase/Adaptors, Immunology/Inflammation, JAK/STAT signaling, Chromatin/Epigenetic, Stem Cells, Angiogenesis

Bioactivity

TYK2-IN-12 (compound 30) is a selective, orally active inhibitor of TYK2 (tyrosine kinase 2) (Ki: 0.51 nM) . It inhibits IL-12-induced IFNγ in human and mouse whole blood with IC50 values of 2.7 and 7.0 μM, respectively, and can be used to study psoriasis.

Smiles

N(C1=C2C(=NC(=C1)C3=C(F)C=CC=C3F)CNC2=O)C4=CC=C(C(=O)N5CCCC5)C=C4

Molecular Formula

C24H20F2N4O2

Molecular Weight

434.44

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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