HIV-1 inhibitor-25
Product Specifications
CAS Number
2475658-74-1
Target
Others, HIV Protease
Related Pathways
Microbiology/Virology, Others, Proteases/Proteasome
Bioactivity
HIV-1 inhibitor-25 (compound R-12a) is a potent inhibitor of HIV-1 reverse transcription (HIV-1 RT) with an IC50 of 0.1061 nM. It exhibits a high antiviral effect against wild-type HIV-1 (EC50: 13.6 nM) and demonstrates low cytotoxicity (to MT) . It also inhibits HIV-1 mutants (L100I, K103 N, Y181C, Y188L, E138K, F227L+V106A) with EC50 values ranging from 0.1961 to 5.8136 μM. HIV-1 inhibitor-25 is useful for studying AIDS.
Smiles
[C@@H](O)(C1=C(OC)C=C(C=C1)C2=CC=C(C#N)C=C2)C3=NC(NC4=CC=C(C#N)C=C4)=NC=C3
Molecular Formula
C26H19N5O2
Molecular Weight
433.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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