HIV-1 inhibitor-24
Product Specifications
CAS Number
2475658-75-2
Target
Others, HIV Protease
Related Pathways
Proteases/Proteasome, Others, Microbiology/Virology
Bioactivity
HIV-1 inhibitor-24 (compound S-12a) is a potent inhibitor of HIV-1 reverse transcription (HIV-1 RT) with an IC50 of 9.5 nM. It exhibits a high antiviral effect on wild-type HIV-1, showing an EC50 value of 1.6 nM and low cytotoxicity (CC50 on MT-4 cells) . HIV-1 inhibitor-24 was well tolerated in mice at a dose of 2 g/kg and demonstrated a significant cardiovascular safety profile.
Smiles
[C@H](O)(C1=C(OC)C=C(C=C1)C2=CC=C(C#N)C=C2)C3=NC(NC4=CC=C(C#N)C=C4)=NC=C3
Molecular Formula
C26H19N5O2
Molecular Weight
433.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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