MELK-8a

Product Specifications

CAS Number

1922153-17-0

Target

Haspin Kinase|||Others|||PDGFR|||MELK

Related Pathways

Cell Cycle/Checkpoint|||Tyrosine Kinase/Adaptors|||PI3K/Akt/mTOR signaling|||Angiogenesis|||Others

Bioactivity

MELK-8a (NVS-MELK8a) is a potent and selective inhibitor of maternal embryonic leucine zipper kinase (MELK), with an IC50 of 2 nM and an IC50 of 0.42 ?M in cellular assays. MELK is crucial in regulating mitosis in cancer cells.

Smiles

O(CC1CCNCC1)C=2C(=CC=NC2)C3=CN(N=C3)C4=CC=C(C=C4)N5CCN(C)CC5

Molecular Formula

C25H32N6O

Molecular Weight

432.56

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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