FLT3-IN-12
Product Specifications
CAS Number
2499966-67-3
Target
Others, FLT
Related Pathways
Others, Tyrosine Kinase/Adaptors, Angiogenesis
Bioactivity
FLT3-IN-12 is a selective, potent, orally active FLT3 kinase inhibitor that acts on FLT3-WT (IC50: 1.48 nM) and FLT3-D835Y (IC50: 2.87 nM) . FLT3-IN-12 is more selective than c-KIT (>1000-fold) . FLT3-IN-12 showed significant anti-AML effects, with an IC50 value of 0.75 nM for MV4-11 cells.
Smiles
O=C1C=2C(=CC(NC=3N=C(N[C@@H]4CC[C@H](N)CC4)C(C(F)(F)F)=CN3)=CC2)C=CN1C
Molecular Formula
C21H23F3N6O
Molecular Weight
432.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
RD21492F-01 25 µg
PE/Cyanine5.5 Anti-Mouse Ly-6G/Ly-6C (Gr-1) Antibody
Sign In for Pricing
View Details RD21492F-02 100 µg
PE/Cyanine5.5 Anti-Mouse Ly-6G/Ly-6C (Gr-1) Antibody
Sign In for Pricing
View Details MBS1415345-01 0.02 mg (E-Coli)
Recombinant Thermobifida fusca 2-phospho-L-lactate transferase (cofD)
Sign In for Pricing
View Details MBS1415345-02 0.02 mg (Yeast)
Recombinant Thermobifida fusca 2-phospho-L-lactate transferase (cofD)
Sign In for Pricing
View Details MBS1415345-03 0.1 mg (E-Coli)
Recombinant Thermobifida fusca 2-phospho-L-lactate transferase (cofD)
Sign In for Pricing
View Details