FLT3-IN-12
Product Specifications
CAS Number
2499966-67-3
Target
Others|||FLT
Related Pathways
Others|||Tyrosine Kinase/Adaptors|||Angiogenesis
Bioactivity
FLT3-IN-12 is a selective, potent, orally active FLT3 kinase inhibitor that acts on FLT3-WT (IC50: 1.48 nM) and FLT3-D835Y (IC50: 2.87 nM) . FLT3-IN-12 is more selective than c-KIT (>1000-fold) . FLT3-IN-12 showed significant anti-AML effects, with an IC50 value of 0.75 nM for MV4-11 cells.
Smiles
O=C1C=2C(=CC(NC=3N=C(N[C@@H]4CC[C@H](N)CC4)C(C(F)(F)F)=CN3)=CC2)C=CN1C
Molecular Formula
C21H23F3N6O
Molecular Weight
432.44
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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