GGTI-286
Product Specifications
CAS Number
171744-11-9
Target
Others, Ras
Related Pathways
Others, MAPK, GPCR/G Protein
Bioactivity
GGTI-286 is a potent, cell permeable GGTase I inhibitor (IC50: 2 μM) . GGTI-286 inhibits Rap1A geranylation in NIH3T3 cells (IC50: 2 μM) more potently than H-Ras farnesylation (IC50>30 μM) . Ras4B stimulation (IC50: 1 μM) .
Smiles
C(N[C@H](C(OC)=O)CC(C)C)(=O)C1=C(C=C(NC[C@H](CS)N)C=C1)C2=CC=CC=C2
Molecular Formula
C23H31N3O3S
Molecular Weight
429.58
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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