VVD-118313
Product Specifications
CAS Number
2875046-27-6
Target
STAT, JAK, Interleukin, Others, IFNAR
Related Pathways
Tyrosine Kinase/Adaptors, JAK/STAT signaling, Angiogenesis, Stem Cells, Immunology/Inflammation, Others, Chromatin/Epigenetic
Bioactivity
VVD-118313 (compound 5a), a potent, selective JAK1 inhibitor, targets an isoform-restricted allosteric cysteine to inhibit JAK1-dependent trans-phosphorylation and cytokine signaling. This compound is utilized in cancer research [1].
Smiles
C(C#C[C@@H]1CN(S(C)(=O)=O)CC1)(=O)N2C[C@@H](CCC2)C3=CC(Cl)=C(Cl)C=C3
Molecular Formula
C19H22Cl2N2O3S
Molecular Weight
429.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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