α7 nAchR-JAK2-STAT3 agonist 1
Product Specifications
CAS Number
2108714-20-9
Target
JAK, STAT, Others, AChR, NO Synthase
Related Pathways
Stem Cells, Neuroscience, Others, Angiogenesis, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic, JAK/STAT signaling, Immunology/Inflammation
Bioactivity
α7 nAchR-JAK2-STAT3 agonist 1 is a potent inhibitor of the α7 nAchR-JAK2-STAT3 pathway that acts on nitric oxide (NO) (IC50: 0.32 μM) . It has demonstrated positive effects on iNOS, IL-1β, and IL-1β in murine macrophages RAW264.7, and inhibited the expression of iNOS, IL-1β, and IL-6 in mouse macrophages. Additionally, α7 nAchR-JAK2-STAT3 agonist 1 suppressed LPS-induced NO release, NF-κB activation, and cytokine production, making it useful for studying sepsis.
Smiles
O(C(C)=O)C1=C(OC(C)=O)C=CC(CC[C@H](CCCCC2=CC=CC=C2)OC(C)=O)=C1
Molecular Formula
C25H30O6
Molecular Weight
426.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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