PHD2/HDACs-IN-1
Product Specifications
CAS Number
2339867-53-5
Target
Others|||HIF/HIF Prolyl-Hydroxylase|||HDAC
Related Pathways
Metabolism|||Others|||DNA Damage/DNA Repair|||Chromatin/Epigenetic
Bioactivity
PHD2/HDACs-IN-1 is a potent mixed inhibitor of PHD2/HDACs, acting on PHD2 (IC50: 1.15 ?M), HDAC1 (IC50: 19.75 ?M), HDAC2 (IC50: 26.60 ?M), and HDAC16 (IC50: 15.98 ?M) . HDACs-IN-1 is a low toxicity nephroprotective agent suitable for studies of cisplatin-induced acute kidney injury (AKI) .
Smiles
O=C1NC(=NC=C1C(NC2CCN(CC2)C=3N=CC(C(NO)=O)=CN3)=O)N4C=CC=N4
Molecular Formula
C18H19N9O4
Molecular Weight
425.4
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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