FLT3-IN-11
Product Specifications
CAS Number
2499966-50-4
Target
Others, FLT
Related Pathways
Tyrosine Kinase/Adaptors, Others, Angiogenesis
Bioactivity
FLT3-IN-11 (compound 30) is an orally active, potent, and selective inhibitor of FLT3 kinase that targets wild-type FLT3 (IC50: 7.22 nM) and FLT3-D835Y (IC50: 4.95 nM), demonstrating significant anti-AML effects with an IC50 value of 3.2 nM for MV4-11 cells.
Smiles
N(C=1C(C(F)(F)F)=CN=C(NC2=CC=C(C(N(C)C)=O)C=C2)N1)[C@@H]3CC[C@H](N)CC3
Molecular Formula
C20H25F3N6O
Molecular Weight
422.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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