NLRP3-IN-8
Product Specifications
CAS Number
2768650-56-0
Target
Others, NOD-like Receptor (NLR)
Related Pathways
Others, Immunology/Inflammation
Bioactivity
NLRP3-IN-8 (compound 27), an orally active NLRP3 inflammasome inhibitor, directly binds to its target with an IC50 of 1.23 μM for IL-1β inhibition. It demonstrates robust metabolic stability in liver microsomes (t1/2 = 138.63 min) and exhibits minimal toxicity (against L02: IC50 > 100 μM) [1].
Smiles
C(=C/N(=O)=O)\C1=C(/C=C/C2=CC=C(NC(=O)C3=CC=CO3)C=C2)C=C(OC)C=C1OC
Molecular Formula
C23H20N2O6
Molecular Weight
420.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
PKSH031554 20 µg
Recombinant Human ADAM15 Protein (HEK293 Cells, His Tag)
Sign In for Pricing
View Details 
E-AB-V1322-01 20 µL
Anti-West Nile Virus (WNV) (lineage 1, strain NY99) E/Envelope Polyclonal Antibody
Sign In for Pricing
View Details E-AB-V1322-02 100 µL
Anti-West Nile Virus (WNV) (lineage 1, strain NY99) E/Envelope Polyclonal Antibody
Sign In for Pricing
View Details