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Selumetinib

Product Specifications

CAS Number

606143-52-6

Target

ERK, MEK, Apoptosis

Related Pathways

MAPK, Apoptosis

Purity

0.999

Bioactivity

Selumetinib (AZD6244) is a MEK1/2 inhibitor that inhibits MEK1 (IC50=14 nM) with potent selectivity and is non-ATP-competitive. Selumetinib has antitumor activity and is used for the treatment of neurofibromatosis type 1 (NF1) .

Smiles

CN1C=NC2=C(F)C(NC3=CC=C(Br)C=C3Cl)=C(C=C12)C(=O)NOCCO

Molecular Formula

C17H15BrClFN4O3

Molecular Weight

457.68

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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