HIV-1 inhibitor-16
Product Specifications
CAS Number
2719675-72-4
Target
Others|||HIV Protease
Related Pathways
Microbiology/Virology|||Others|||Proteases/Proteasome
Bioactivity
HIV-1 inhibitor-16 (compound 7a) is a potent HIV-1 inhibitor with an EC50 of 1.3 nM against wild-type HIV-1, and exhibits inhibitory activity against HIV-1 K103N, E138K, Y181C, and L100I strains with EC50s of 5.4 nM, 9.2 nM, 22 nM, and 35 nM, respectively. It demonstrates good solubility, hepatic microsomal stability, and lacks significant CYP enzyme inhibitory activity or acute toxicity.
Smiles
FC=1C=C(C=C(F)C1NC2=NC(NC3=CC=C(C#N)C=C3)=NC=C2C)C=4C=CN=CC4
Molecular Formula
C23H16F2N6
Molecular Weight
414.41
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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