FNDR-20123
Product Specifications
Target
Parasite, Others, HDAC
Related Pathways
DNA Damage/DNA Repair, Others, Chromatin/Epigenetic, Microbiology/Virology
Bioactivity
FNDR-20123 is the first safe and effective anti-malarial HDAC inhibitor, acting on both Plasmodium falciparum HDAC (IC50: 31 nM) and human HDAC (IC50: 3 nM) . FNDR-20123 inhibited HDAC1 (IC50: 25 nM), HDAC2 (IC50: 29 nM), HDAC3 (IC50: 2 nM), HDAC6 (IC50: 11 nM), HDAC8 (IC50: 282 nM) and, at nanomolar concentrations, HDAC3 (IC50: 2 nM) . The inhibitor of HDAC subtype III was also observed at nanomolar concentrations.
Molecular Formula
C21H24ClN5O2
Molecular Weight
413.9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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