GSK3494245
Product Specifications
CAS Number
2080410-41-7
Target
Parasite, Proteasome, Others
Related Pathways
Ubiquitination, Microbiology/Virology, Others, Proteases/Proteasome
Purity
0.9585
Bioactivity
GSK3494245 (DDD01305143) is a potent, selective, orally active inhibitor of chymotrypsin-like activity that binds to the proteasome of WTL.donovani (IC50: 0.16 μM), sandwiched between the β4 and β5 subunits, exhibiting good biosafety properties and suitability for inhibiting chymotrypsin-like activity of the human proteasome (IC50: 26S=13 μM; enriched THP-1 extract IC50=40 μM) .
Smiles
Fc1ccc(NC(=O)N2CCCC2)cc1-c1ccn2c(cnc2n1)N1CCOCC1
Molecular Formula
C21H23FN6O2
Molecular Weight
410.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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