MYF-03-176
Product Specifications
CAS Number
2857937-59-6
Target
YAP
Related Pathways
Stem Cells
Bioactivity
MYF-03-176 is an orally active TEAD1/3/4 inhibitor with IC50 values of 47/32/71 nM, respectively. It also inhibits TEAD transcriptional activity and cell growth in NCI-H226 cells, exhibiting antitumour activity in malignant pleural mesothelioma (MPM) cells with defective Hippo signalling and in mouse xenograft models.
Smiles
O(CC1=CC=C(C(F)(F)F)C=C1)[C@H]2[C@H](NC=3N=CC=CN3)CN(C(C(=C)F)=O)C2
Molecular Formula
C19H18F4N4O2
Molecular Weight
410.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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