HDAC6-IN-5
Product Specifications
CAS Number
2413603-15-1
Target
Others, Beta Amyloid, Cholinesterase (ChE), HDAC
Related Pathways
DNA Damage/DNA Repair, Neuroscience, Chromatin/Epigenetic, Others
Bioactivity
HDAC6-IN-5 (compound 11b) is a potent and BBB-penetrated inhibitor of HDAC6 (IC50 = 0.025 μM) that inhibits Aβ 1-42 self-aggregation and AChE with IC50 values of 3.0 and 0.72 μM, respectively. Additionally, HDAC6-IN-5 can enhance neurite outgrowth without significant neurotoxicity.
Smiles
N(C=1C2=C(N=C3C1C=CC=C3)C=CC(Br)=C2)C4=CC=C(C(NO)=O)C=C4
Molecular Formula
C20H14BrN3O2
Molecular Weight
408.25
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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