SKI-I
Product Specifications
CAS Number
306301-68-8
Target
Apoptosis, Others, S1P Receptor
Related Pathways
GPCR/G Protein, Others, Apoptosis
Bioactivity
SKI-I is a potent and selective inhibitor of human sphingosine kinase (SK), with an IC50 of 1.2 μM for ST-hSK, and also inhibits hERK2 (IC50 = 11 μM) . SKI-I induces apoptosis in tumor cell lines.
Smiles
Oc1ccc2ccccc2c1\C=N\NC(=O)c1cc([nH]n1)-c1ccc2ccccc2c1
Molecular Formula
C25H18N4O2
Molecular Weight
406.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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