SHP2-IN-8
Product Specifications
CAS Number
1801692-60-3
Target
Others, Phosphatase, Apoptosis, Akt
Related Pathways
Cytoskeletal Signaling, Metabolism, Others, Apoptosis, PI3K/Akt/mTOR signaling
Bioactivity
SHP2-IN-8 is a reversible, noncompetitive, selective and efficient allosteric SHP2 inhibitor (IC50=23 nM, Ki=22 nM), which also has effects in cells. SHP2-IN-8 can cause significant thermal displacement (Δ Tm = 7.01 °C) . SHP2-IN-8 can inhibit the phosphorylation of AKT and induce apoptosis of Hela cells.
Smiles
NC=1N=C(N2CCC(CN)(C)CC2)C=NC1SC3=C(Cl)C(Cl)=CC=C3
Molecular Formula
C17H21Cl2N5S
Molecular Weight
398.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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