γ-Secretase modulator 12
Product Specifications
CAS Number
2204249-82-9
Target
Beta Amyloid, Gamma-secretase, Others
Related Pathways
Others, Proteases/Proteasome, Neuroscience, Stem Cells
Bioactivity
γ-Secretase modulator 12 (Compound 1a) is a selective compound that effectively reduces amyloid-β42 (Aβ42) levels with an IC50 of 0.39 μM, specifically designed for Alzheimer's disease research. Notably, γ-Secretase modulator 12 exhibits a favorable brain/plasma ratio (Kp, brain = 0.72) in mice [1].
Smiles
CC1=C(N2C(C(OCC3=CC=CC=C3)=CC=C2)=N1)C=4C=C5C(=CC4)C(=O)N(CC)C5
Molecular Formula
C25H23N3O2
Molecular Weight
397.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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