Trk-IN-10
Product Specifications
CAS Number
2700265-61-6
Target
Trk receptor|||Others
Related Pathways
Others|||Tyrosine Kinase/Adaptors
Bioactivity
Trk-IN-10 (Compound 14j) is a highly effective inhibitor of TRK, with an IC50 of 0.86 nM against TrkA and 6.92 nM against TrkA G595R. As an RTK, Trk is a crucial drug target in solid tumors. Trk-IN-10 (IC50 = 350 nM against ALK) demonstrates superior selectivity in inhibiting Trk, potentially reducing toxicity [1].
Smiles
C[C@H]1N2C=3C(=CN4C(N3)=C(C=N4)C(=O)NC[C@H](C)OC=5C(C2)=CC=C(F)C5)OC1
Molecular Formula
C20H20FN5O3
Molecular Weight
397.4
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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