Samuraciclib
Product Specifications
CAS Number
1805833-75-3
Target
Others, Apoptosis, CDK
Related Pathways
Cell Cycle/Checkpoint, Others, Apoptosis
Bioactivity
Samuraciclib (CT7001) is a potent, selective, and orally active CDK7 inhibitor with an ATP-competitive nature, effectively inhibiting CDK7 with an IC50 of 41 nM. It demonstrates 45-fold, 15-fold (IC50 of 578 nM), 230-fold, and 30-fold selectivity over CDK1, CDK2, CDK5, and CDK9, respectively. Samuraciclib inhibits the growth of breast cancer cell lines with GI50 values of 0.2-0.3 μM and possesses anti-tumor effects [1] [2].
Smiles
N(CC1=CC=CC=C1)C=2N3C(=C(C(C)C)C=N3)N=C(NC[C@@H]4[C@@H](O)CNCC4)C2
Molecular Formula
C22H30N6O
Molecular Weight
394.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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