ISRIB (trans-isomer)
Product Specifications
CAS Number
1597403-47-8
Target
Autophagy, Apoptosis, PERK
Related Pathways
Autophagy, Apoptosis
Purity
0.9927
Bioactivity
ISRIB (trans-isomer) is a potent inhibitor of PERK (IC50=5 nM) that restores protein translation and prevents SG formation in the presence of P-eIF2α.
Smiles
Clc1ccc(OCC(=O)N[C@H]2CC[C@@H](CC2)NC(=O)COc2ccc(Cl)cc2)cc1
Molecular Formula
C22H24Cl2N2O4
Molecular Weight
451.34
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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