ISRIB (trans-isomer)

1597403-47-8

Autophagy, Apoptosis, PERK

Autophagy, Apoptosis

0.9927

ISRIB (trans-isomer) is a potent inhibitor of PERK (IC50=5 nM) that restores protein translation and prevents SG formation in the presence of P-eIF2α.

Clc1ccc(OCC(=O)N[C@H]2CC[C@@H](CC2)NC(=O)COc2ccc(Cl)cc2)cc1

C22H24Cl2N2O4

451.34

Ice Packs

-20°C