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M1002

Product Specifications

CAS Number

823830-85-9

Target

HIF/HIF Prolyl-Hydroxylase|||HIF

Related Pathways

Chromatin/Epigenetic|||Metabolism|||Angiogenesis

Purity

0.9998

Bioactivity

M1002 is a hypoxia-inducible factor-2 (HIF-2) agonist that enhances the affinity of HIF-2alpha and ARNT for transcriptional activation. It alters the Tyr2 conformation of the HIF-2alpha PAS-B structural domain and acts synergistically with inhibitors of the prolyl hydroxylase structural domain (PHD) .

Smiles

FC(F)(F)C1=CC(=CC(NC2=NS(=O)(=O)C3=CC=CC=C23)=C1)C(F)(F)F

Molecular Formula

C15H8F6N2O2S

Molecular Weight

394.29

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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