JAK3-IN-9
Product Specifications
CAS Number
1430095-30-9
Target
Others|||JAK
Related Pathways
Tyrosine Kinase/Adaptors|||Others|||Chromatin/Epigenetic|||JAK/STAT signaling|||Angiogenesis|||Stem Cells
Bioactivity
JAK3-IN-9 is a potent and orally active inhibitor of the Janus kinase 3 (JAK3) enzyme, displaying an impressive IC50 value of 1.7 nM. It exhibits high selectivity towards the JAK3 signaling pathway, making it a valuable tool for studying autoimmune diseases. Additionally, JAK3-IN-9 possesses desirable characteristics such as low toxicity and excellent oral bioavailability. It also demonstrates promising anti-arthritis activity, thus enhancing its potential as a therapeutic agent [1].
Smiles
N([C@@H](C(C)C)C)C=1C(C(N)=O)=CN=C(NC2=CC=C(OS(C)(=O)=O)C=C2)N1
Molecular Formula
C17H23N5O4S
Molecular Weight
393.46
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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