ATR-IN-14
Product Specifications
CAS Number
2765785-88-2
Target
Others, ATM/ATR
Related Pathways
PI3K/Akt/mTOR signaling, Others, DNA Damage/DNA Repair
Bioactivity
ATR-IN-14 (compound 1) is a powerful ATR kinase inhibitor that significantly inhibits ATR signaling pathways following CHKI protein phosphorylation, with a remarkable inhibition rate of 98.03% at 25 nM. ATR-IN-14 also exhibits notable anticancer efficacy in LoVo cells, displaying an IC50 value of 64 nM [1].
Smiles
FC=1C2=C(C(=NC1)C=3C=CNN3)N=C(C=C2C=4N(C)N=CC4)N5[C@H](C)COCC5
Molecular Formula
C20H20FN7O
Molecular Weight
393.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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