E6201
Product Specifications
CAS Number
603987-35-5
Target
FLT, MEK, Others
Related Pathways
MAPK, Others, Tyrosine Kinase/Adaptors, Angiogenesis
Bioactivity
E6201 (ER-806201) is a potent dual kinase inhibitor targeting MEK1 and FLT3, inhibiting their activities in an ATP-competitive manner. It effectively suppresses MEK1-induced ERK2 phosphorylation (IC50 = 5.2 nM), MKK4-induced JNK phosphorylation (IC50 = 91 nM), and MKK6-induced p38 MAPK phosphorylation (IC50 = 19 nM) . E6201 exhibits anti-tumor and anti-psoriasis effects [1] [2].
Smiles
OC1=C2C(=CC(NCC)=C1)/C=C/C[C@H](O)[C@H](O)C(=O)\C=C\[C@@H](C)[C@H](C)OC2=O
Molecular Formula
C21H27NO6
Molecular Weight
389.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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