Dyrk1A-IN-5
Product Specifications
CAS Number
1685235-41-9
Target
Others, DYRK
Related Pathways
Tyrosine Kinase/Adaptors, Others, Cell Cycle/Checkpoint
Bioactivity
Dyrk1A-IN-5 (compound 5j) is a highly potent and selective DYRK1A inhibitor with an IC50 of 6 nM, reducing the phosphorylation of Thr434 in SF3B1 dose-dependently (IC50 = 0.5 μM) and inhibiting tau phosphorylation at Thr212 (IC50 = 2.1 μM), making it valuable for Down syndrome research [1].
Smiles
C(O)(=O)C1=C2C(=C3C(=N1)C=CC=C3)NC=4C2=CC=CC4I
Molecular Formula
C16H9IN2O2
Molecular Weight
388.16
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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