Osunprotafib
Product Specifications
CAS Number
2489404-97-7
Target
STAT, JAK, Phosphatase
Related Pathways
Angiogenesis, Chromatin/Epigenetic, Tyrosine Kinase/Adaptors, Stem Cells, JAK/STAT signaling, Metabolism
Purity
>99.99%
Bioactivity
Osunprotafib (ABBV-CLS-484) is a potent, orally bioavailable PTP1B/PTPN2 inhibitor in clinical trials for solid tumors. [1] Osunprotafib (ABBV-CLS-484) stimulates the tumor microenvironment and promotes natural killer cell and CD8 T cell function and enhances T cell anti-tumor immunity by enhancing JAK-STAT signaling and reducing T cell dysfunction. [2]
Smiles
CC(C)CCN[C@@H]1CCc2cc(O)c(N3CC(=O)NS3(=O)=O)c(F)c2C1
Molecular Formula
C17H24FN3O4S
Molecular Weight
385.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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